What are the beneficial potentials of collagen peptides for health?
In recent years, an increasing number of research findings have indicated a diversity of bioactivities for collagen hydrolysates or peptides. Moreover, the bioactivities of some collagen peptides have been confirmed by in vivo animal models and human clinical trials.
1. Bone and joint health
Scientific evidence suggests that collagen peptides exert a positive therapeutic effect on osteoarthritis. In vitro cell studies have revealed that collagen hydrolysates/peptides stimulate the synthesis of proteoglycans and collagen in human chondrocytes. Meantime, the clinical studies have shown that intake of collagen peptides (5 g/day for 12 weeks) can lead to the relief of joint pain and stimulate reconstruction of type II collagen and the biosynthesis of proteoglycans in cartilage tissue osteoarthritis patients.
2. Skin health
Collagen peptides can stimulate proliferation and motility of fibroblasts, increase the density and diameter of collagen fibers, promote the production of hyaluronic acid, elevate the expression of type I and IV collagen. Several controlled clinical trials have indicated the benefits of collagen peptides on skin properties, including hydration, skin elasticity, and the decline of wrinkles.
3. Protein source
Collagen peptides are fat- and carbohydrate-free protein source with unique nutritional and amino acid profiles to help stimulate collagen synthesis in humans. Furthermore, protein supplementation has become more crucial to diets, especially for older people with low food intake.
4. Antihypertensive and Angiotensin-I converting enzyme (ACE) inhibitory activity
Hypertension represents one of the significant risk factors for developing cardiovascular diseases. Angiotensin-I converting enzyme (ACE) plays an essential physiological role in the regulation of blood pressure and electrolyte homeostasis. Thus, effective inhibition of ACE has been considered the primary target for the treatment of hypertension. Many identified collagen peptides with ACE-inhibitory activities are mainly extracted from fish skins. The ACE-inhibitory properties of collagen peptides are closely related to their unique amino acid compositions. Collagen peptides also appear to promote elasticity of the blood vessel endothelium.